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Genome Res ; 30(11): 1593-1604, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-33060172

RESUMO

The effect of drought on maize yield is of particular concern in the context of climate change and human population growth. However, the complexity of drought-response mechanisms makes the design of new drought-tolerant varieties a difficult task that would greatly benefit from a better understanding of the genotype-phenotype relationship. To provide novel insight into this relationship, we applied a systems genetics approach integrating high-throughput phenotypic, proteomic, and genomic data acquired from 254 maize hybrids grown under two watering conditions. Using association genetics and protein coexpression analysis, we detected more than 22,000 pQTLs across the two conditions and confidently identified 15 loci with potential pleiotropic effects on the proteome. We showed that even mild water deficit induced a profound remodeling of the proteome, which affected the structure of the protein coexpression network, and a reprogramming of the genetic control of the abundance of many proteins, including those involved in stress response. Colocalizations between pQTLs and QTLs for ecophysiological traits, found mostly in the water deficit condition, indicated that this reprogramming may also affect the phenotypic level. Finally, we identified several candidate genes that are potentially responsible for both the coexpression of stress response proteins and the variations of ecophysiological traits under water deficit. Taken together, our findings provide novel insights into the molecular mechanisms of drought tolerance and suggest some pathways for further research and breeding.


Assuntos
Proteínas de Plantas/genética , Polimorfismo de Nucleotídeo Único , Proteoma/genética , Zea mays/genética , Secas , Meio Ambiente , Genes de Plantas , Genoma de Planta , Estudo de Associação Genômica Ampla , Proteínas de Plantas/metabolismo , Proteoma/metabolismo , Locos de Características Quantitativas , Zea mays/metabolismo
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